After surviving the fall from their hotel room window, Duane Bradley and his misshapen, basket-dwelling brother Belial are taken to the city hospital. Meanwhile, Duane's long-lost Aunt learns of their situation and, along with her daughter Susan, helps them escape from the confines of the hospital and the eye of the press. Duane and Belial's aunt, known as Granny Ruth, takes them under her wing at her mansion, which serves as a safe haven for hideously deformed freaks of all shapes and sizes. Unfortunately, the whereabouts of this dynamic duo don't remain secret for too long, and Duane and Belial team up with Susan, Granny Ruth, and her houseful of mutants to devise a plan to do away with exploitative reporters.